Gene information
Official symbol IRS1
Official full name insulin receptor substrate 1
Gene type protein-coding gene
Chromosome2q36.3
Alias symbolHIRS-1
Gene familyPleckstrin homology domain containing
Resources
Entrez Gene 3667
HGNC HGNC:6125
Ensembl ENSG00000169047
Vega OTTHUMG00000133179
UCSC uc002voh.5
GO terms: 103 records
GO Description Category LogP Number of genes Detail
GO:0002791 regulation of peptide secretion GO Biological Processes -16.5189310 23 More
GO:0002792 negative regulation of peptide secretion GO Biological Processes -6.38368268 7 More
GO:0005080 protein kinase C binding GO Molecular Functions -2.10003506 7 More
GO:0005158 insulin receptor binding GO Molecular Functions -2.72529058 5 More
GO:0005159 insulin-like growth factor receptor binding GO Molecular Functions -3.41433421 5 More
GO:0005901 caveola GO Cellular Components -18.8033423 19 More
GO:0005979 regulation of glycogen biosynthetic process GO Biological Processes -6.48443546 10 More
GO:0006109 regulation of carbohydrate metabolic process GO Biological Processes -13.1742479 35 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0008286 insulin receptor signaling pathway GO Biological Processes -3.0699689 9 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0009896 positive regulation of catabolic process GO Biological Processes -13.5088608 63 More
GO:0010565 regulation of cellular ketone metabolic process GO Biological Processes -15.3155739 32 More
GO:0010675 regulation of cellular carbohydrate metabolic process GO Biological Processes -9.60411715 27 More
GO:0010676 positive regulation of cellular carbohydrate metabolic process GO Biological Processes -6.37680507 13 More
GO:0010817 regulation of hormone levels GO Biological Processes -29.5190556 49 More
GO:0010827 regulation of glucose transmembrane transport GO Biological Processes -18.4601079 28 More
GO:0010828 positive regulation of glucose transmembrane transport GO Biological Processes -9.82015489 15 More
GO:0010906 regulation of glucose metabolic process GO Biological Processes -10.3110629 25 More
GO:0010907 positive regulation of glucose metabolic process GO Biological Processes -8.00848642 13 More
GO:0010962 regulation of glucan biosynthetic process GO Biological Processes -6.48443546 10 More
GO:0014065 phosphatidylinositol 3-kinase signaling GO Biological Processes -6.54430115 7 More
GO:0019216 regulation of lipid metabolic process GO Biological Processes -24.8423986 38 More
GO:0019217 regulation of fatty acid metabolic process GO Biological Processes -12.5607102 15 More
GO:0019900 kinase binding GO Molecular Functions -6.03057706 62 More
GO:0019901 protein kinase binding GO Molecular Functions -6.66055444 59 More
GO:0030971 receptor tyrosine kinase binding GO Molecular Functions -4.12949610 12 More
GO:0031331 positive regulation of cellular catabolic process GO Biological Processes -13.5134767 30 More
GO:0031998 regulation of fatty acid beta-oxidation GO Biological Processes -2.92503639 5 More
GO:0032868 response to insulin GO Biological Processes -11.6850377 35 More
GO:0032869 cellular response to insulin stimulus GO Biological Processes -9.16399556 26 More
GO:0032870 cellular response to hormone stimulus GO Biological Processes -24.7707938 79 More
GO:0032881 regulation of polysaccharide metabolic process GO Biological Processes -7.60302561 13 More
GO:0032885 regulation of polysaccharide biosynthetic process GO Biological Processes -7.40593429 12 More
GO:0033500 carbohydrate homeostasis GO Biological Processes -23.7918768 50 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0034762 regulation of transmembrane transport GO Biological Processes -31.7284805 100 More
GO:0034764 positive regulation of transmembrane transport GO Biological Processes -18.2616571 46 More
GO:0042593 glucose homeostasis GO Biological Processes -23.8963802 50 More
GO:0043235 receptor complex GO Cellular Components -19.4198369 40 More
GO:0043255 regulation of carbohydrate biosynthetic process GO Biological Processes -8.87798147 21 More
GO:0043434 response to peptide hormone GO Biological Processes -26.1739008 69 More
GO:0043467 regulation of generation of precursor metabolites and energy GO Biological Processes -10.8295915 27 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0043550 regulation of lipid kinase activity GO Biological Processes -3.76907414 6 More
GO:0043551 regulation of phosphatidylinositol 3-kinase activity GO Biological Processes -3.24021630 5 More
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity GO Biological Processes -4.38579065 5 More
GO:0044853 plasma membrane raft GO Cellular Components -18.4542052 33 More
GO:0045121 membrane raft GO Cellular Components -30.0775030 71 More
GO:0045725 positive regulation of glycogen biosynthetic process GO Biological Processes -5.96315455 7 More
GO:0045834 positive regulation of lipid metabolic process GO Biological Processes -24.1838255 28 More
GO:0045913 positive regulation of carbohydrate metabolic process GO Biological Processes -10.1978214 20 More
GO:0045923 positive regulation of fatty acid metabolic process GO Biological Processes -10.6446744 10 More
GO:0046320 regulation of fatty acid oxidation GO Biological Processes -3.51698265 7 More
GO:0046324 regulation of glucose import GO Biological Processes -14.8736114 22 More
GO:0046326 positive regulation of glucose import GO Biological Processes -7.69659659 12 More
GO:0046626 regulation of insulin receptor signaling pathway GO Biological Processes -7.79385832 16 More
GO:0046627 negative regulation of insulin receptor signaling pathway GO Biological Processes -4.76875730 9 More
GO:0046628 positive regulation of insulin receptor signaling pathway GO Biological Processes -3.92081595 4 More
GO:0046676 negative regulation of insulin secretion GO Biological Processes -5.56777868 6 More
GO:0046883 regulation of hormone secretion GO Biological Processes -20.4338227 29 More
GO:0046888 negative regulation of hormone secretion GO Biological Processes -8.59327523 10 More
GO:0048015 phosphatidylinositol-mediated signaling GO Biological Processes -5.56029805 8 More
GO:0048017 inositol lipid-mediated signaling GO Biological Processes -5.38623088 8 More
GO:0050708 regulation of protein secretion GO Biological Processes -30.3716714 63 More
GO:0050709 negative regulation of protein secretion GO Biological Processes -12.5236372 21 More
GO:0050796 regulation of insulin secretion GO Biological Processes -13.8348879 19 More
GO:0050994 regulation of lipid catabolic process GO Biological Processes -9.86212956 11 More
GO:0050996 positive regulation of lipid catabolic process GO Biological Processes -5.87603013 9 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051048 negative regulation of secretion GO Biological Processes -20.2278199 42 More
GO:0051051 negative regulation of transport GO Biological Processes -46.8709407 107 More
GO:0051223 regulation of protein transport GO Biological Processes -25.2801266 81 More
GO:0051224 negative regulation of protein transport GO Biological Processes -11.0190941 26 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0062012 regulation of small molecule metabolic process GO Biological Processes -26.8746473 69 More
GO:0062013 positive regulation of small molecule metabolic process GO Biological Processes -17.9792910 37 More
GO:0070201 regulation of establishment of protein localization GO Biological Processes -24.4831554 82 More
GO:0070542 response to fatty acid GO Biological Processes -13.2686457 21 More
GO:0070873 regulation of glycogen metabolic process GO Biological Processes -6.66615417 11 More
GO:0070875 positive regulation of glycogen metabolic process GO Biological Processes -5.72938190 7 More
GO:0071375 cellular response to peptide hormone stimulus GO Biological Processes -15.9961580 44 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0071398 cellular response to fatty acid GO Biological Processes -4.09043632 8 More
GO:0071417 cellular response to organonitrogen compound GO Biological Processes -26.3253267 90 More
GO:0090087 regulation of peptide transport GO Biological Processes -16.3568662 23 More
GO:0090218 positive regulation of lipid kinase activity GO Biological Processes -5.34310134 6 More
GO:0090276 regulation of peptide hormone secretion GO Biological Processes -16.6841590 23 More
GO:0090278 negative regulation of peptide hormone secretion GO Biological Processes -6.46280795 7 More
GO:0098797 plasma membrane protein complex GO Cellular Components -14.6387951 39 More
GO:0098802 plasma membrane signaling receptor complex GO Cellular Components -6.47096721 17 More
GO:0098857 membrane microdomain GO Cellular Components -30.8181788 72 More
GO:1900077 negative regulation of cellular response to insulin stimulus GO Biological Processes -5.46127869 10 More
GO:1900078 positive regulation of cellular response to insulin stimulus GO Biological Processes -3.69512980 4 More
GO:1901652 response to peptide GO Biological Processes -34.9047734 89 More
GO:1901653 cellular response to peptide GO Biological Processes -21.5212108 58 More
GO:1901699 cellular response to nitrogen compound GO Biological Processes -26.9091664 96 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:1903531 negative regulation of secretion by cell GO Biological Processes -17.4034654 36 More
GO:1903828 negative regulation of protein localization GO Biological Processes -8.86943289 30 More
GO:1904950 negative regulation of establishment of protein localization GO Biological Processes -11.4813166 27 More
GO:1990782 protein tyrosine kinase binding GO Molecular Functions -4.10270724 15 More
KEGG pathways: 15 records
KEGG Description Category LogP Number of genes Detail
hsa04022 cGMP-PKG signaling pathway KEGG Pathway -9.74555098 16 More
hsa04068 FoxO signaling pathway KEGG Pathway -6.87449445 21 More
hsa04140 Autophagy - animal KEGG Pathway -3.52554737 16 More
hsa04150 mTOR signaling pathway KEGG Pathway -2.57210479 7 More
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
hsa04152 AMPK signaling pathway KEGG Pathway -7.66810818 12 More
hsa04211 Longevity regulating pathway KEGG Pathway -6.96966761 10 More
hsa04213 Longevity regulating pathway - multiple species KEGG Pathway -4.02893527 6 More
hsa04920 Adipocytokine signaling pathway KEGG Pathway -10.4150431 19 More
hsa04923 Regulation of lipolysis in adipocytes KEGG Pathway -8.97402692 10 More
hsa04930 Type II diabetes mellitus KEGG Pathway -3.96920305 9 More
hsa04931 Insulin resistance KEGG Pathway -8.40376708 21 More
hsa04932 Non-alcoholic fatty liver disease KEGG Pathway -11.2628136 17 More
hsa04935 Growth hormone synthesis, secretion and action KEGG Pathway -2.82078524 13 More
hsa05010 Alzheimer disease KEGG Pathway -5.39034067 17 More
Drug-Gene interaction
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Related drugs: 7 records
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
NM_005544.3:c.2911G>A genomics angiotensin-converting enzyme 2[other] acute ST elevation myocardial infarction Liu W et al. Cardiovasc Diabetol. 2013
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